Treatments include topical steroids, oral antihistamines, and cool compresses, but lesions are usually self-limiting.Sweet syndrome-like local reactions have been reported.Pink plaques are variably oedematous and typically homogenous or less commonly annular. ![]() Median development of 7 days after vaccine administration with a median duration of 5 days, but can persist for up to 21 days.The COVID-19 vaccines may cause a delayed localized hypersensitivity reaction presenting as a pruritic and painful erythematous reaction near the injection site.Delayed large local reaction (“COVID arm").Common sites include the arm (62%), legs (27%), and trunk (42%).Common sites include arms (68%), trunk (57%), and legs (46%).Median onset reported on day 2–3 after vaccination.Median onset of 1 day after vaccination.Swelling, erythema, and pain in the vaccinated arm.The spectrum of reported cutaneous reactions after mRNA vaccination include: The majority of current literature regarding cutaneous reactions relate specifically to mRNA COVID-19 vaccinations. What are the common types of skin reaction to COVID-19 vaccines? Protein subunit vaccines eg, Novavax (not yet approved in any country).Inactivated virus eg, Sinopharm + China National Biotec Group Co. ![]() Viral vector platforms eg, AstraZeneca + University of Oxford, Janssen Pharmaceutical.Messenger ribonucleic acid ( mRNA) eg, Pfizer/BioNTech + Fosun Pharma, Moderna + National Institute of Allergy and Infectious Diseases.How do the COVID-19 vaccines differ?Ĭurrent approved vaccines rely on a nucleic-acid-based vaccine platform ![]() More than 100 companies and institutions worldwide have developed vaccine candidates. The coronavirus disease 2019 (COVID-19) pandemic has led to the development and approval of vaccines against the responsible virus - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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